First Presbyterian Church of St. Louis
is a PC(USA) Church.

The PC(USA) denomination is the largest Presbyterian denomination in the United States. The PC(USA) supports evangelical feminism and same sex marriages. It also welcomes gay and lesbian persons to serve in leadership positions as ministers, deacons, elders, and trustees.

First Presbyterian Church of St. Louis is in the Synod of Mid America and is a member of the Giddings-Lovejoy Presbytery.